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My two are on Vectra 3D...so far, so good. No fleas and no reaction to the medicine. It's nice because it also repels ticks and mosquitoes. Just keep Charlotte away from cats until it dries, as it's poisonous to them. I usually put it on them when they are settled in for the night and finished wrestling. Cats won't bother them...they aren't fond of dogs
 
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