Can you gate off that room? Is it a rug that can be removed? My basset Snickers likes to go on the carpet in the doorway of my bedroom and our office. We've used enzyme cleaner everytime. I finally bought it in the gallon jug and drench the spot after getting as much of the urine up as possible. So, we just keep the door closed and put up a gate to the hall leading to the office. So, basically we've gated off the family room and kitchen (no carpet). She's 11 months old now, and accidents are at a minimum. (as sure as I brag on her she will have a couple of accidents, happens every time) Are you putting enough enzyme cleaner on that spot? doesn't hurt to rule out the uti tho.