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pano is self regulating in that over time once the dog stops growing it resolves itself. The pain can be intense for the dog If the dog lost 8lbs inorder to loss that much weight that quickly a large portion has to be fluids. I would be worryied about dehydration even with sub Q's. Never had a problem with mine eat with pano. I would not be surprised if the cause of the not eating is still not gastrointestinal related. If he drinks but does not eat you can try substituting low sodium, chicken stock for water.

FWIW pano ussually begins in the front end given you said knee I am assuming he is limping on a back leg.
 

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As for the refusal of food and water, that could be explained by the pain. Vet thinks he isn't eating because he is in such severe pain
I have never had a basset not eat because of an orthopeadic condition regardless the amount of pain. The only time they did not eat was a gasticor mouth issue or an over all systemic problem ie cancer . Is it possible that the dog is not eat because of the pain of pano? yes. but given the number of dogs / basset hound that do not have similar reaction and the accomanying gastric problem with the cow hoof, I would be concerned the vet is taking the easy answer and not the correct one
 

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From what i read here this could last 3 weeks?
The pain in one leg but pano tends to effect more than one limb on a revolving basis. I had on dog effect on and of from the age of 5 month to 18 months with every limb effect twice and one of the fore limbs 3 times.
 

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They are supposed to be indestructable,
they are far from industructable. you need a cow or elephant hock/knuckle for that. Mine have access to them all the time. but I have had two of the harder chewers break rear most mollars which may be bcause of the hooves. The are more industructable than raw hide and the like but some of the thinner sides can shatter into rather sharp shards. Theorretically they are digestible, ie keratin, but, given the dogs digestive system not very likely. There is no 100% safe chew toy, for my guy's I find them one of the safer ones on the market, but what is best for an individual dog is highly variable. They also tend to have a rather strong odor.
 
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