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By way of the canine genetics list.
Tissue Antigens
Volume 68 Issue 6 Page 502 - December 2006
Volume 68 Issue 6

Association of a common dog leucocyte antigen class II haplotype with canine
primary immune-mediated haemolytic anaemia
L. J. Kennedy1, A. Barnes2, W. E. R. Ollier1 & M. J. Day3

Immune-mediated haemolytic anaemia (IMHA) is the commonest immune-mediated
disease of the dog, representing a major health concern to this species. The
aim of this investigation was to determine whether genetic susceptibility to
IMHA is associated with genes of the canine major histocompatibility complex
(MHC; dog leucocyte antigen system, DLA). Samples were collected from 108 dogs
with primary idiopathic, Coombs' positive IMHA. This diseased population was
subdivided on the basis of Coombs' test results into two groups: 1) dogs
with dominant warm-reactive immunoglobulin (Ig) G haemagglutinins and (2) dogs
with an additional or dominant cold-reactive IgM haemagglutinin. The DLA class
II alleles and haplotypes of the diseased population were characterised, and
these data were compared with those derived from a breed-matched control
cohort and a much larger group of DLA-typed dogs. Two haplotypes were increased
in the patient group: DLA-DRB1*00601/DQA1*005011/DQB1*00701 (in the group
with warm-reactive IgG haemagglutinins only) and
DLA-DRB1*015/DQA1*00601/DQB1*00301 (in both groups, but more so in the group with cold-reactive IgM
haemagglutinins). One haplotype, DLA-DRB1*001/DQA1*00101/DQB1*00201, was decreased in
the total patient group, but this decrease was limited to the warm-reactive
IgG haemagglutinins group, and it was actually increased in the cold-reactive
IgM haemagglutinins group. A second haplotype,
DLA-DRB1*015/DQA1*00601/DQB1*02301, was also decreased in the total patient group, and this decrease was
found in both subgroups. In addition, all haplotypes carrying DLA-DRB1*001
were significantly increased in the cold-reactive IgM haemagglutinins group.
When the overall patient group was divided on the basis of individual breeds
with more than six animals represented, each of the haplotypes could be shown to
be implicated in one of the breeds. Thus, it was apparent that different
breeds had different MHC associations with canine IMHA, which is similar to the
observation that different human ethnic groups can have different HLA
associations with the same immune-mediated disease.[/b]
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