Gene found 4 Canine Thyroid Disease
reprinted with permission from email to "Harrier" group
Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.
L. J. Kennedy, S. Quarmby, G. M. Happ, A. Barnes, I. K. Ramsey, R. M.
Dixon, B. Catchpole, C. Rusbridge, P. A. Graham, N. S. Hillbertz, C.
Roethe,W. J. Dodds, N. G. Carmichael,W. E. Ollier Tissue Antigens 2006;
68(1) :82-86.
the pdf is available online from George Happ's website:
Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele
Abstract:
Dogs exhibit a range of immune-mediated conditions including a
lymphocytic thyroiditis which has many similarities to Hashimoto's
thyroiditis in man. We have recently reported an association in Doberman
Pinschers between canine hypothyroidism and a rare DLA class II haplotype
that contains the DLA-DQA1*00101 allele. We now report a further series
of 173 hypothyroid dogs in a range of breeds where a significant
association with DLA-DQA1*00101 is shown.
Bottom line here is a conformation and more compelling evidence that
the most common form of thyroid disease in dogs is typically a highly
heritable disease associated wtih specific genes. All the more reason to
test dogs using the OFA "gold standard" for thyroid testing (FT4D, cTSH,
TgAA) which distinguished between variants of thyroid disease and even
stages of this common, heritable disease, not only to screen to treat
dogs with the disease early and so more effectively, but also to be able
to better organize breeding plans to manage the expression of these
genes.
It's worth noting also that for all thyroid disease typically is"easily"
treated with an inexpensive daily supplement, the underlying defect
here is one of self-recognition, and the relentless destruction of the
thyroid gland that results from such immune dysfunction. This sort of DLA
gene problem means dogs with thyroid disease can also have Addison's or
diabetes, for example, or have close relatives with these other endocrine
defects. So the strong indication is that these same few genes are behind
several different forms of endocrine disease. And so this one gene
<<DLA_DQA1*00101>>could be behind
several diseases that may appear different in symptoms but are similar
in origin and identical in cause--this one gene.
other links
Evidence for extensive DNA polymorphisms in different dog populations.
Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs.
Association of hypothyroid disease in Doberman Pinscher dogs with a rare major histocompatibility complex DLA class II haplotype.
Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.
L. J. Kennedy, S. Quarmby, G. M. Happ, A. Barnes, I. K. Ramsey, R. M.
Dixon, B. Catchpole, C. Rusbridge, P. A. Graham, N. S. Hillbertz, C.
Roethe,W. J. Dodds, N. G. Carmichael,W. E. Ollier Tissue Antigens 2006;
68(1) :82-86.
the pdf is available online from George Happ's website:
Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele
Abstract:
Dogs exhibit a range of immune-mediated conditions including a
lymphocytic thyroiditis which has many similarities to Hashimoto's
thyroiditis in man. We have recently reported an association in Doberman
Pinschers between canine hypothyroidism and a rare DLA class II haplotype
that contains the DLA-DQA1*00101 allele. We now report a further series
of 173 hypothyroid dogs in a range of breeds where a significant
association with DLA-DQA1*00101 is shown.
Bottom line here is a conformation and more compelling evidence that
the most common form of thyroid disease in dogs is typically a highly
heritable disease associated wtih specific genes. All the more reason to
test dogs using the OFA "gold standard" for thyroid testing (FT4D, cTSH,
TgAA) which distinguished between variants of thyroid disease and even
stages of this common, heritable disease, not only to screen to treat
dogs with the disease early and so more effectively, but also to be able
to better organize breeding plans to manage the expression of these
genes.
It's worth noting also that for all thyroid disease typically is"easily"
treated with an inexpensive daily supplement, the underlying defect
here is one of self-recognition, and the relentless destruction of the
thyroid gland that results from such immune dysfunction. This sort of DLA
gene problem means dogs with thyroid disease can also have Addison's or
diabetes, for example, or have close relatives with these other endocrine
defects. So the strong indication is that these same few genes are behind
several different forms of endocrine disease. And so this one gene
<<DLA_DQA1*00101>>could be behind
several diseases that may appear different in symptoms but are similar
in origin and identical in cause--this one gene.
other links
Evidence for extensive DNA polymorphisms in different dog populations.
Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs.
Association of hypothyroid disease in Doberman Pinscher dogs with a rare major histocompatibility complex DLA class II haplotype.
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