Finally, owners should consider whether the pet is comfortable with traveling. Pets are just like people who sometimes become anxious when they don’t travel frequently. This leads some owners and veterinarians to question whether administering sedatives or tranquilizers to dogs or cats prior to flight is a good idea. According to national and international air transportation organizations, as well as the American Humane Association and the American Veterinary Medical Association, in most cases the answer is "no"! "An animal’s natural ability to balance and maintain equilibrium is altered under sedation," says Dr. Patricia Olson, DVM, PhD, former director of veterinary affairs and studies for the American Humane Association. "When the kennel is moved, a sedated animal may not be able to brace and prevent injury."
Whether flying in the cabin or as checked baggage, animals are exposed to increased altitude pressure of approximately 8,000 feet. Increased altitude, according to Dr. Olson, can create respiratory and cardiovascular problems for dogs and cats who are sedated or tranquilized. "Brachycephalic dogs and cats [those with short, wide heads] are especially affected," says Dr. Olson. "Although thousands of pets are transported uneventfully by air, airline officials believe that when deaths occur they often result from the use of sedation."